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HRID1483090

反应详情

EQUATION

反应方程式

HRID 1483090 的结构方程式

REACTANTS

反应物

2
结构：FCCBr
HCID12982

2-Bromofluoroethane

C2H4BrF

结构：CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1
HCID44631912

Ribociclib

C23H30N8O

PRODUCTS

生成物

1
结构：CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(CCF)CC4)cn3)nc2n1C1CCCC1
HCID44818220

未命名化合物

收率 80%

PROCEDURE

实验过程

Following General Procedure D, 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (100 mg, 0.229 mmol) and 1-bromo-2-fluoroethane (88 mg, 0.687 mmol) gave 7-cyclopentyl-2-{5-[4-(2-fluoro-ethyl)-piperazin-1-yl]-pyridin-2-ylamino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (51 mg, 80%).