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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14831Generated: October 25, 2026

tert-Butyl 3-(aminomethyl)pyrrolidine-1-carboxylate → 3-{[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/14831

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 3-(aminomethyl)pyrrolidine-1-carboxylateHCID 2756485—
Reactant3-(2-Chloro-pyrimidin-4-yl)-benzaldehydeHCID 24901965—
Product3-{[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl esterHCID 86603279—

Reaction Steps

Intermediate 1 was coupled with 3-Aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 403.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732444B2
Source datasetuspto-grants-2010_06
ORD IDord-90a6330773f14fc6afd87a1a5c12a5a6
Source noteuspto-grants-2010_06