1-Penten-3-one → HCID 90034429, compound

Participants

Reaction Steps

A 100 mL round-bottomed flask was charged with 1 g (2.9 mmol, 1 eq.) of griseofulvic acid, 0.34 g (4.4 mmol, 1.5 eq.) ammonium acetate and 347 μL (3.5 mmol, 1.2 eq.) of ethyl vinyl ketone in 10 mL ethanol. The mixture was left under agitation for 4 h at 80° C., cooled to ambient temperature then concentrated under reduced pressure. The residue was purified by chromatography on silica gel (CH2Cl2/AcOEt 98:2 to 80:20). A yellow solid (0.25 g) was obtained with a yield of 21%.

Provenance & Evidence