Triphenylphosphine → HCID 71601674, compound

Participants

Reaction Conditions

Reaction Steps

Compound 27c (4.8 g, 20 mmol) was dissolved in tetrahydrofuran (10 mL). Under the protection of argon, PPh3 (5.8 g, 22 mmol) was added, and the reaction mixture was heated to 45° C. to react for 2 hrs. Then water (7.86 mL) was added and the mixture was cooled to room temperature to react for 13 hrs. TLC (dichloromethane/methanol=20/1) was employed to monitor the reaction. After the reaction completed, the mixture was diluted with water, and extracted with ethyl acetate. The organic phase was combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and then dried by rotary evaporation. Column chromatography afforded 4.0 g of white solid (compound 27d), yield 93.2%.

Provenance & Evidence