HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 118480344, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,5-Dibromopyridine | HCID 69353 | — |
| Reactant | HCID 84038454 | HCID 84038454 | — |
| Reactant | HCID 118480346 | HCID 118480346 | — |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Product | HCID 118480344 | HCID 118480344 | 97% |
Reaction Steps
3-oxopiperidin-1-benzyl formate (860 mg, 2.67 mmol), 2,5-dibromopyridine (949 mg, 4.01 mmol), cesium carbonate (1.74 g, 5.34 mmol), Pd2(dba)3 (127 mg, 0.13 mmol) and xantphos (92.3 mg, 0.16 mmol) reacted following the synthetic method of compound 19a to afford 1 g of white solid, yield 97%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09416144B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-6d64eff9605e4326ab32b066d580a03f |
| Source note | uspto-grants-2016_08 |