HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dichloroethane → 2',3',5'-Tri-o-benzoyl-5-azacytidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dichloroethane | HCID 6365 | — |
| Reactant | Tin tetrachloride | HCID 24287 | — |
| Reactant | beta-D-Ribofuranose, 1-acetate 2,3,5-tribenzoate | HCID 81455 | — |
| Reactant | HCID 178508820 | HCID 178508820 | — |
| Product | 2',3',5'-Tri-o-benzoyl-5-azacytidine | HCID 12907232 | — |
Reaction Steps
U.S. Pat. No. 3,819,780 discloses a process which involves reacting a bis-silyl compound of 5-Azacytosine with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose in the presence of SnCl4 and absolute dichloroethane to give 5-azacytidine tribenzoate, which is further reacted with methanolic ammonia to give 5-azacytidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09416152B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-4cd5f25f30d54d4eb581152789897355 |
| Source note | uspto-grants-2016_08 |