Ethanolamine → HCID 22060429, compound

HRID 1483511Notes

Reaction equation

HRID 1483511 reaction equation
C(OC(C=N[C:8]1[CH:9]=[C:10]([NH:14][C:15]2[N:20]=[C:19]([NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([OH:28])[CH:23]=3)[C:18]([F:29])=[CH:17][N:16]=2)[CH:11]=[CH:12][CH:13]=1)=O)C.[NH2:30][CH2:31][CH2:32][OH:33]>>[F:29][C:18]1[C:19]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([OH:28])[CH:23]=2)=[N:20][C:15]([NH:14][C:10]2[CH:11]=[CH:12][CH:13]=[C:8]([N:30]=[CH:31][C:32]([NH:30][CH2:31][CH2:32][OH:33])=[O:33])[CH:9]=2)=[N:16][CH:17]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 22061087HCID 22061087, compound

Product 1

HCID 22060429HCID 22060429, compound

Procedure

In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-[3-(N-morpholinoethyleneamino)carbonylmethyleneaminophenyl]-2,4-pyrimidinediamine, N2-(3-ethoxycarbonylmethyleneaminophenyl)-5-fluoro-N4-(3-hydroxyphenyl)-2,4-pyrimidinediamine and 2-aminoethanol were reacted to prepare 5-fluoro-N4-(3-hydroxyphenyl)-N2-[3-(N2-hydroxyethylamino)carbonylmethyleneaminophenyl]-2,4-pyrimidinediamine. LCMS: ret. time: 13.28 min.; purity: 97.3%; MS (m/e): 413.04 (MH+).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-18e2da419b424c739df2f2e515a6cd46
Source dataset
uspto-grants-2016_08
Patent number
US09416112B2

Reaction notes

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