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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1483549Generated: October 29, 2026

2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine → HCID 178516085, compound

https://huagongshe.com/reaction/1483549

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamineHCID 22060451—
ReactantHCID 178507526HCID 178507526—
ProductHCID 178516085HCID 178516085—

Reaction Steps

In like manner to the preparation of N4-(3-chloro-4-trifluoromethoxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidineamine, the reaction of 2-chloro-5-fluoro-N4-(3-hydroxyphenyl)-4-pyrimidineamine with 3-(1H-pyrazol-3-yl)aniline gave 5-fluoro-N4-(3-hydroxyphenyl)-N2-[3-(1H-pyrazol-3-yl)phenyl]-2,4-pyrimidinediamine. LCMS: purity: 84%; MS 363 (MH+)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09416112B2
Source datasetuspto-grants-2016_08
ORD IDord-f3f05974795f4e398f8bf14cbb6e8ba9
Source noteuspto-grants-2016_08