Potassium Carbonate → HCID 57969172, compound

Participants

Reaction Steps

Coupling reaction of 6-chloronicotinaldehyde (5.4 g, 38.15 mmol) and 4-bromo-3-(hydroxymethyl)phenol (8.15 g, 38.15 mmol) in the presence of K2CO3 (8.5 g, 1.5 eq) in DMF (100 mL) for 2 h at 100° C. under N2 gave the desired 6-(4-bromo-3-(hydroxymethyl)phenoxy)nicotinaldehyde (8.03 g, 26.1 mmol, yield 68.3%) as a white solid after silica gel column purification (hexane:EtOAc=3:1, v/v).

Provenance & Evidence