HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1483800Generated: November 3, 2026
Water → 2-[4-(Aminomethyl)piperidin-1-yl]ethan-1-ol
https://huagongshe.com/reaction/1483800
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethyl Sulfide | HCID 1068 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2-Hydroxyethyl)piperidine-4-carbonitrile | HCID 13823155 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[4-(Aminomethyl)piperidin-1-yl]ethan-1-ol | HCID 7330476 | 47.4% |
Reaction Steps
To the solution of compound 1-(2-hydroxyethyl)piperidine-4-carbonitrile (300 mg, 2 mmol) in dry THF (5 mL) at 0° C., BH3.SMe2 (220 mg, 2.4 mmol) was added dropwise. The mixture was stirred at 0° C. for 2 hrs. Water was added then K2CO3. The mixture was filtered and concentrated to give compound 2-(4-(aminomethyl)piperidin-1-yl)ethanol (150 mg, 47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09416132B2 |
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| Source dataset | uspto-grants-2016_08 |
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| ORD ID | ord-6305663d1f8f42548e4053b3e2985a2f |
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| Source note | uspto-grants-2016_08 |
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