Sodium Bicarbonate → 4-((3-(3-Chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanol

Participants

Role	Name	HCID	Charge
Reactant	Sodium Bicarbonate	HCID 516892	—
Reactant	6-Chloro-3-(3-chlorophenyl)imidazo[1,2-b]pyridazine	HCID 57418686	—
Reactant	HCID 178479278	HCID 178479278	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	4-((3-(3-Chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanol	HCID 66598229	31%

Reaction Conditions

Temperature	180 °C

Reaction Steps

To a solution of 6-chloro-3-(3-chlorophenyl)imidazo[1,2-b]pyridazine (300 mg, 1.14 mmol) and trans-4-aminocyclohexanol hydrogenchloride (327 mg, 2.84 mmol) in NMP (2.0 mL) was added NaHCO3 (286 mg, 3.41 mmol), the mixture was stirred at 180° C. for 45 mins under microwave irridation. The mixture was purified by flash chromatograph to give 4-((3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanol (120 mg, 0.350 mmol, 31%) as a pale yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09416132B2
Source dataset	uspto-grants-2016_08
ORD ID	ord-cb6cdb7f9c8a43c7ad71a5998b5c390f
Source note	uspto-grants-2016_08