Sodium Bicarbonate → 4-((3-(3-Chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanone

Participants

Role	Name	HCID	Charge
Reactant	Sodium Bicarbonate	HCID 516892	—
Reactant	4-Aminocyclohexanone	HCID 9912306	—
Reactant	6-Chloro-3-(3-chlorophenyl)imidazo[1,2-b]pyridazine	HCID 57418686	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	4-((3-(3-Chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanone	HCID 71227728	16%

Reaction Conditions

Temperature	180 °C

Reaction Steps

To a solution of 6-chloro-3-(3-chlorophenyl)imidazo[1,2-b]pyridazine (200 mg, 0.757 mmol) and 4-aminocyclohexanone (290 mg, 2.56 mmol) in NMP (1.0 mL) was added NaHCO3 (118 mg, 1.52 mmol), the mixture was stirred at 180° C. for 60 mins under microwave irridation. The mixture was purified by flash chromatograph to give 4-((3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanone (40 mg, 0.117 mmol, 16%) as a pale yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09416132B2
Source dataset	uspto-grants-2016_08
ORD ID	ord-3c89b3d9381a45dab39d4b1daffda2f8
Source note	uspto-grants-2016_08