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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1483841Generated: October 30, 2026

Ethyl Acetate → HCID 89389893, compound

https://huagongshe.com/reaction/1483841

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl AcetateHCID 8857—
ReactantHCID 71227791HCID 71227791—
CatalystPalladium hydroxideHCID 9942167—
SolventEthanolHCID 702—
ProductHCID 89389893HCID 8938989377%

Reaction Steps

A mixture of 2-(trans-3-(dibenzylamino)cyclopentyl)propan-2-ol (3 g, 9.3 mmol) and Pd(OH)2 (900 mg) in EtOH (30 mL) was hydrogenated under 50 psi of H2 for 48 h at room temperature. TLC (PE:EA=5:1) showed the reaction was complete. The mixture was filtered and concentrated in vacuo to give crude 2-(trans-3-aminocyclopentyl)propan-2-ol (1 g, 77%) as a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09416132B2
Source datasetuspto-grants-2016_08
ORD IDord-f5a31d661d0443e68b6cdd43e9ce8a61
Source noteuspto-grants-2016_08