反应详情

To a solution of ethyl 2-(pyrimidin-4-yl)acetate (Example 33b, 450 mg, 2.71 mmol) in ethanol (5 mL) was added 2N NaOH (2 mL) at room temperature under nitrogen. The reaction mixture was stirred at room temperature under nitrogen for 24 hours, concentrated under reduced pressure and suspended in ethanol. The solid was removed by vacuum filtration, and the filtrate was concentrated under reduced pressure, triturated with ethanol, concentrated again and carried onto the next step without further purification. MS 139 (MH+).

1. concentrationconcentrated under reduced pressure
2. customThe solid was removed by vacuum filtration
3. concentrationthe filtrate was concentrated under reduced pressure
4. customtriturated with ethanol
5. concentrationconcentrated again
6. customcarried onto the next step without further purification