Sucrose → Phentermine

Participants

Reaction Steps

Preparation method: 74.7 g of phentermine hydrochloride (corresponding to 60 g of phentermine) that passed through 80-mesh sieve was weighed, 6.0 g of hydropropylmethylcellulose (HPMC) was weighed as binding agent, they were added with 200 ml of water, stirred and dissolved under heating at 40° C.-50° C., and added with water to reach 300 ml, to obtain a drug-containing coating solution. 400 g of sucrose pellet core (0.71-0.85 mm) was placed in a fluidized bed bottom spray coating pan, inlet air temperature was set at 50-70° C., inlet air pressure was 0.35 bar, atomization pressure was 1.0-2.0 bar, solution spray rate was 3-12 g/min (regulated according to fluidization state at any time). The drug-containing coating solution was sprayed in manner of bottom spray on surface of blank pellet cores when the sucrose pellet cores were in fluidization state, after end of drug-loading, the material was further fluidized at 45° C. for 5 min, and then taken out to obtain drug-loaded pellet of phentermine.

Provenance & Evidence