1-Cyanocyclopropanecarboxylic acid → HCID 68182753, compound

HRID 1484075Notes

Reaction equation

HRID 1484075 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[CH2:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1)[CH2:8]2.[C:27]([C:29]1([C:32](O)=[O:33])[CH2:31][CH2:30]1)#[N:28]>>[CH:3]12[CH2:9][CH:7]3[CH2:6][CH:5]([CH2:10][CH:1]([CH2:8]3)[CH:2]1[CH2:11][O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([NH:24][C:32]([C:29]3([C:27]#[N:28])[CH2:31][CH2:30]3)=[O:33])=[CH:25][CH:26]=1)[CH2:4]2

Participants

3

Reactant 2

HCID 27332591-Cyanocyclopropanecarboxylic acidHCID 66927331HCID 66927331, compound

Product 1

HCID 68182753HCID 68182753, compoundYield 96.2%

Procedure

General procedure E was used to convert 1.30 mmol of 13d and 1.95 mmol of 1-cyanocyclopropanecarboxylic acid to 1.25 mmol (96%) of the title compound.

Sources & evidence

ORD record
ord-c7fada14105f43b1a24df12cc7ae03cb
Source dataset
uspto-grants-2016_08
Patent number
US09421177B2

Reaction notes

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