1-Cyanocyclopropanecarboxylic acid → HCID 53248322, compound

HRID 1484079Notes

Reaction equation

HRID 1484079 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:22]([C:24]1([C:27](O)=[O:28])[CH2:26][CH2:25]1)#[N:23]>>[C:22]([C:24]1([C:27]([NH:19][C:18]2[CH:17]=[CH:16][C:15]([CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:21][CH:20]=2)=[O:28])[CH2:26][CH2:25]1)#[N:23]

Participants

3

Reactant 2

HCID 27332591-Cyanocyclopropanecarboxylic acidHCID 53248320HCID 53248320, compound

Product 1

HCID 53248322HCID 53248322, compoundYield 98.4%

Procedure

General procedure E was used to convert 3.15 mmol of 17a and 4.73 mmol of 1-cyanocyclopropanecarboxylic acid to 3.10 mmol (98%) of the title compound.

Sources & evidence

ORD record
ord-359ec7e6379c463d9d76cf5fb6bec36b
Source dataset
uspto-grants-2016_08
Patent number
US09421177B2

Reaction notes

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