Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 3-(3-Bromo-5-fluorophenyl)-3-hydroxypropanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 3-Bromo-5-fluorobenzaldehyde | HCID 21986246 | — |
| 생성물 | 3-(3-Bromo-5-fluorophenyl)-3-hydroxypropanenitrile | HCID 68940532 | — |
반응 단계
Alkylation of 3-bromo-5-fluorobenzaldehyde with acetonitrile following the method used in Example 50 except KOBu-t was used instead of LDA gave 3-(3-bromo-5-fluorophenyl)-3-hydroxypropanenitrile as a light color oil. Yield (2.5 g, 86%): 1H NMR (400 MHz, CDCl3) δ 7.34 (bs, 1H), 7.21-7.24 (m, 1H), 7.08-7.11 (m, 1H), 5.02 (t, J=6.4 Hz, 1H), 2.75 (d, J=6.4 Hz, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09421210B2 |
| 출처 데이터셋 | uspto-grants-2016_08 |
| ORD ID | ord-7fc38646df6741328c58d2e3b68a8a5d |
| 출처 메모 | uspto-grants-2016_08 |