Ginsenoside Rb1 → ginsenoside F2

HRID 1484199Notes

Reaction equation

HRID 1484199 reaction equation
[CH3:1][C:2]([CH3:77])=[CH:3][CH2:4][CH2:5][C@:6]([O:54][C@@H:55]1[O:60][C@H:59]([CH2:61][O:62][C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H:58]([OH:74])[C@H:57]([OH:75])[C@H:56]1[OH:76])([C@@H:8]1[C@H:12]2[C@H:13]([OH:52])[CH2:14][C@@H:15]3[C@@:20]4([CH3:50])[CH2:21][CH2:22][C@H:23]([O:27][C@@H:28]5[O:33][C@H:32]([CH2:34][OH:35])[C@@H:31]([OH:36])[C@H:30]([OH:37])[C@H:29]5[O:38][C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C:24]([CH3:26])([CH3:25])[C@@H:19]4[CH2:18][CH2:17][C@@:16]3([CH3:51])[C@:11]2([CH3:53])[CH2:10][CH2:9]1)[CH3:7]>O>[CH3:1][C:2]([CH3:77])=[CH:3][CH2:4][CH2:5][C@:6]([O:54][C@@H:55]1[O:60][C@H:59]([CH2:61][OH:62])[C@@H:58]([OH:74])[C@H:57]([OH:75])[C@H:56]1[OH:76])([C@@H:8]1[C@H:12]2[C@H:13]([OH:52])[CH2:14][C@@H:15]3[C@@:20]4([CH3:50])[CH2:21][CH2:22][C@H:23]([O:27][C@@H:28]5[O:33][C@H:32]([CH2:34][OH:35])[C@@H:31]([OH:36])[C@H:30]([OH:37])[C@H:29]5[OH:38])[C:24]([CH3:25])([CH3:26])[C@@H:19]4[CH2:18][CH2:17][C@@:16]3([CH3:51])[C@:11]2([CH3:53])[CH2:10][CH2:9]1)[CH3:7]

Participants

3

Reactant 1

HCID 9898279Ginsenoside Rb1

Product 1

HCID 9918692ginsenoside F2Yield 96.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

200 g ginsenoside Rb1 with high purity is taken into reaction vessel, 500 ml of purified water is added, and alpha-galactosidase is added, it is decomposed by enzymolysis at 30° C. for 4˜44 hours (more preferably 8˜12 hours, extracted with 200 ml n-butanol for three times, and the n-butanol is combined, concentrated under reduced pressure and dried to obtain 136 g ginsenoside F2.

Workup

  1. additionis added
  2. additionalpha-galactosidase is added
  3. waitit is decomposed by enzymolysis at 30° C. for 4˜44 hours
  4. extraction(more preferably 8˜12 hours, extracted with 200 ml n-butanol for three times
  5. concentrationconcentrated under reduced pressure
  6. customdried

Sources & evidence

ORD record
ord-44b1bc51ea46453b8307e5648553e066
Source dataset
uspto-grants-2016_08
Patent number
US09421269B2

Reaction notes

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