(R)-((S)-1-phenylethyl)2-(2-fluorophenyl)-2-(piperidin-1-yl)acetate → (R)-2-(2-fluorophenyl)-2-(piperidin-1-yl)acetic acid

Participants

Reaction Steps

A mixture of (R)—((S)-1-phenylethyl) 2-(2-fluorophenyl)-2-(piperidin-1-yl)acetate (0.737 g, 2.16 mmol) and 20% Pd(OH)2/C (0.070 g) in ethanol (30 mL) was hydrogenated at room temperature and atmospheric pressure (H2 balloon) for 2 hours. The solution was then purged with Ar, filtered through diatomaceous earth (Celite®), and concentrated in vacuo. This provided the title compound as a colorless solid (0.503 g, 98%).

Provenance & Evidence