Sulfuric acid magnesium salt (1:1) → 4'-Methoxyacetophenone

Participants

Reaction Conditions

Reaction Steps

Wet Raney Ni 4200 was dried under vacuum and carefully weight (20 mg (dry weight), 3.5×10−4 mol, 250 mol %). 4 mL degassed heptane was added, followed by 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-ol (38 mg, 1.4×10−4 mol). The reaction was heated at 120° C. for 24 hours. Workup: The reaction was cooled, opened and 10 mg of NH4COOH was added. 50 mL of Et2O was used to transfer the crude to an erlenmeyer containing MgSO4. After drying the solution was filtered and concentrated. HNMR gave 100% conversion to 1-(4-methoxyphenyl)ethan-1-one, 100% of the β-O-4 bond was broken.

Provenance & Evidence