Trifluoroacetic acid → HCID 117662140, compound

Participants

Reaction Steps

To a solution of (4S,5R)-tert-butyl 4-(fluoromethyl)-2,2-dimethyl-5-(4-(methyl-N-(2,2,2-trifluoroacetyl)sulfonimidoyl)phenyl)oxazolidine-3-carboxylate (500 mg, 1.168 mmol) in DCM (20 mL) is added Trifluoroacetic acid (2.0 mL). Reaction mixture is allowed to stir at room temperature for 2 h. Excess of Trifluoroacetic acid and DCM is evaporated in vacuo, stripped with toluene followed by washing with n-pentane and diethyl ether to afford crude title compound (426 mg, TFA salt) as faint yellow sticky mass which is used as such for next step.

Provenance & Evidence