Potassium Carbonate → HCID 117662125, compound

Participants

Reaction Steps

To a solution of 2, 2-Dichloro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-(methyl-N-(2,2,2-trifluoroacetyl)sulfonimidoyl)phenyl)-ethyl]-acetamide (212 mg, 0.468 mmol) in Methanol (20 mL) is added K2CO3 (322.9 mg, 2.34 mmol) the resulting reaction mixture is stirred at room temperature for 16 h. Solvent is evaporated in vacuo to get crude which is purified by combi-flash chromatography using 15% MeOH in DCM as an eluent and washed with n-pentane and diethyl ether to afford title compound (80 mg). 1H-NMR (400 MHz, DMSO) δ: 1.60 (bs, 2H), 3.04 (s, 3H), 4.13-4.15 (m, 1.5H), 4.21-4.42 (m, 0.5H), 4.42-4.31 (m, 0.5H), 4.39-4.43 (m, 0.5H), 4.66 (bs, 1H), 7.55 (d, J=8.28 Hz, 2H), 7.87 (d, J=8.32 Hz, 2H). LC-MS (m/z): M+H=247.2.

Provenance & Evidence