Benzyl Bromide → HCID 89588561, compound

Participants

Reaction Conditions

Reaction Steps

3-(4-Bromo-phenyl)-7-fluoro-4H-benzo[f][1,4]oxazepin-5-one (7.0 g, 0.021 mol) was dissolved in toluene (100 mL). Benzyl bromide (4.3 g, 0.025 mol) and Ag2CO3 (8.6 g, 0.031 mol) were added and the reaction mixture was heated at 80° C. until disappearance of the starting material. The solution was filtered through a pad of celite and concentrated to dryness. The crude was purified by flash chromatography on silica gel (n-hexane/EtOAc=7:1) to obtain the title compound (5.3 g, 60% yield) as a thick yellow oil.

Provenance & Evidence