Trifluoroacetic acid methylene chloride → HCID 89588328, compound

Participants

Reaction Steps

{2-[1-Benzyloxy-3-(3,4-dichloro-phenyl)-7-fluoro-isoquinolin-4-yloxy]-ethyl}-carbamic acid tert-butyl ester (85 mg, 0.15 mmol) was treated with trifluoroacetic acid/DCM=1:10 (4.5 mL) and stirred for 8 hs at RT. The reaction mixture was then concentrated under reduced pressure. The resulting crude was taken up with diethyl ether and filtered, thus affording 55 mg of the title compound (76% yield) as a white solid.

Provenance & Evidence