Dimethyl Sulfoxide → HCID 90014581, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-isopropylphenol (174 mg, 1.28 mmol) in DMSO (5 mL) tBuOK (143 mg, 1.28 mmol) was added and the reaction mixture was stirred at 20° C. for 30 mins. 2-chloro-3-methyl-5-nitropyridine (200 mg, 1.16 mmol) was added and the resulting mixture was stirred at 120° C. for 2 hrs. The reaction mixture was cooled to r. t., poured into ice-water (20 ml) and extracted with DCM (3×50 mL). The combined organic layer was dried over Na2SO4, filtered and concentrated to afford the title compound (279 mg) as a light red oil.

Provenance & Evidence