Pyridine → HCID 50910548, compound

Participants

Reaction Steps

N-(3-Aminophenyl)-2-bromobenzamide (50 mg, 0.17 mmol), dichloromethane (1.7 mL), pyridine (17 μL, 0.21 mmol), and isovaleryl chloride (25 μL, 0.21 mmol) were added to a vial with stir bar and stirred for 20 h. The reaction was then diluted with ethyl acetate, then the combined organics were washed with 1 M aqueous HCl, then half-saturated aqueous NaHCO3, then brine. The crude solution was dried over Na2SO4, filtered, and concentrated to a colorless oil, then purified by column chromatography (EtOAc/hexanes gradient) after dry-loading on SiO2. The title compound was obtained as a white solid (53 mg, 82%). LRMS (ESI+) (M+H): 375.05.

Provenance & Evidence