反应详情

Following the procedure described for Example 1, 100 mg (0.411 mmol) (2E)-2-[(6-fluoro-3-methyl-1H-indazol-5-yl)methylidene]-3-oxobutanenitrile (Example 4A) were treated with 3-amino-4,4-difluorobut-2-enenitrile. The crude product was purified by preparative RP-HPLC (aceto-nitrile/water+0.1% TFA gradient, final mixture 90:10 v/v) to yield 50 mg (35% of th.) of the racemic title compound.

1. customThe crude product was purified by preparative RP-HPLC (aceto-nitrile/water+0.1% TFA gradient, final mixture 90:10 v/v)