Choline bicarbonate → HCID 178428548, compound

Participants

Reaction Steps

To a suspension of 101 mg (0.30 mmol) (4S)-2-methyl-4-(3-methyl-1H-indazol-5-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3,5-dicarbonitrile (Example 6) in ethanol (2.43 ml) under argon atmosphere was added 52 μl (0.30 mmol) 2-hydroxy-N,N,N-trimethylethanaminium hydrogencarbonate solution (choline bicarbonate, 80% in water), and the mixture was stirred at reflux temperature for 40 min. Subsequently, the solution was evaporated, and the residue was dried in vacuo. The precipitate was stirred in 1.5 ml THF/pentane (9:1 v/v) for 7 days and then centrifuged to yield 70 mg (51% of th.) of the title compound as a solid.

Provenance & Evidence