Sodium Hydroxide → HCID 178428551, compound

Participants

Reaction Steps

To a suspension of 41 mg (0.12 mmol) (4R)-2-methyl-4-(3-methyl-1H-indazol-5-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3,5-dicarbonitrile (Example 5) in THF (1 ml) under argon atmosphere was added 131 μl (0.13 mmol) 1 N aqueous sodium hydroxide solution, and the mixture was stirred under a weak argon stream for 5 days at room temperature. The resulting precipitate was dried in vacuo to yield 44 mg (100% of th.) of the title compound as a solid.

Provenance & Evidence