反应详情

To a suspension of 100 mg (0.28 mmol) 2,6-bis(difluoromethyl)-4-(6-fluoro-3-methyl-1H-indazol-5-yl)-1,4-dihydropyridine-3,5-dicarbonitrile (Example 14) in ethanol (0.25 ml) under argon atmosphere was added 290 μl (0.29 mmol) 1 N aqueous sodium hydroxide solution, and the mixture was stirred under a weak argon stream for 4 days at room temperature. The resulting precipitate was dried in vacuo to yield 110 mg (100% of th.) of the title compound as a solid.

1. customThe resulting precipitate was dried in vacuo