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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1484587Generated: October 30, 2026

3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid → 3-(3-chloro-1H-pyrazol-1-yl)pyridine

https://huagongshe.com/reaction/1484587

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acidHCID 86705825—
CatalystHCID 178419072HCID 178419072—
SolventDimethylacetamideHCID 31374—
Product3-(3-chloro-1H-pyrazol-1-yl)pyridineHCID 67499540—

Reaction Conditions

Temperature125 °C

Reaction Steps

In another embodiment, 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid (4) and copper (I) oxide are mixed with N,N-dimethylacetamide and heated to about 125° C. The 3-(3-chloro-1H-pyrazol-1-yl)pyridine (5b) can be isolated and purified by standard techniques.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09422265B2
Source datasetuspto-grants-2016_08
ORD IDord-78a20fc9126b4ef8977c69f7d587b452
Source noteuspto-grants-2016_08