Trifluoroacetic acid → 2-(5-cyclopropyl-4-methyl-1H-pyrazol-3-yl)-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

Participants

Reaction Conditions

Reaction Steps

880 mg of 2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine (2.0 mmol, 1.00 eq.) were dissolved in 7.8 mL of dry 1,2-dichloroethane. 4.6 mL trifluoroacetic acid (60 mmol, 30 eq.) and 1.8 mL trifluoromethanesulfonic acid (20 mmol, 10 eq.) were added at rt. The reaction mixture was stirred at 75° C. for 2 h. At 0° C. 2M sodiumhydroxide solution was added slowly. The solid was filtered off, dried in vacuo at 50° C. to provide 637 mg (1.96 mmol, 98%) of the analytically pure target compound.

Provenance & Evidence