Hydrogen Peroxide → HCID 71612266, compound

Participants

Reaction Conditions

Reaction Steps

100 mg of 2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-[2-(methylsulfinyl)ethoxy]-N-(pyridin-4-yl)pyrimidin-4-amine (2-8-1, 0.176 mmol, 1.0 eq.) were suspended in 0.93 mL dry tetrahydrofuran under a nitrogen atmosphere. 90 μL hydrogen peroxide (30%, 0.879 mmol, 5.0 eq.) and 33 μL diethyl azodicarboxylate (0.211 mmol, 1.2 eq.) were added. The reaction mixture was stirred at 50° C. for 2 hours and concentrated in vacuo. The crude product was purified by flashcromatography to provide 31.9 mg (0.05 mmol, 31%) of the analytically pure target compound.

Provenance & Evidence