反应详情

To a solution of N-(4-(2,6-dimethyl-4-(4-oxopiperidin-1-yl)phenyl)thiazol-2-yl)isonicotinamide (33 mg, 0.081 mmol) in methanol (5 mL) was added NaBH4 (33 mg, 0.78 mmol). The mixture was stirred for 30 min at rt. Then saturated aqueous NH4Cl solution (2 mL) was added to quench the reaction. The mixture was extracted with EtOAc (5×2 mL). After removal of solvent, the residue was purified on a silica gel column (EtOAc) to provide N-(4-(4-(4-hydroxypiperidin-1-yl)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide as yellow solid (29.8 mg, 90%). MS (ESI) m/z 409.2 (M+H+).

1. customto quench
2. customthe reaction
3. extractionThe mixture was extracted with EtOAc (5×2 mL)
4. customAfter removal of solvent
5. customthe residue was purified on a silica gel column (EtOAc)