反应详情

To a solution of N-(4-(4-(4-(2-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)ethoxy)piperidin-1-yl)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide (4.7 mg, 0.0077 mmol) in EtOH (1 mL) was added Pd/C (10% Pd, 3 mg). The mixture was hydrogenated overnight at room temperature under 1 atm H2 pressure. The mixture was then filtered through a pad of celite and concentrated to give N-(4-(4-(4-(2-(2-(2-(2-amino ethoxy)ethoxy)ethoxy)ethoxy)piperidin-1-yl)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide (1.1 mg, yield 24.5%), which was used directly without further purification.

1. filtrationThe mixture was then filtered through a pad of celite
2. concentrationconcentrated