Thionyl Chloride → HCID 90417196, compound

HRID 1484812Notes

Reaction equation

HRID 1484812 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:13]([CH2:14]O)=[CH:12][CH:11]=[CH:10][N:9]=1.S(Cl)([Cl:18])=O>>[Cl:18][CH2:14][C:13]1[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])=[N:9][CH:10]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 70623920HCID 70623920, compound

Product 1

HCID 90417196HCID 90417196, compoundYield 92%

Procedure

Into a 25-mL round-bottom flask, was placed a solution of [2-(2-chlorophenyl)pyridin-3-yl]methanol (1 g, 4.55 mmol, 1.00 equiv) in thionyl chloride (5 mL). The resulting solution was stirred for 1 h at reflux. The resulting mixture was concentrated under vacuum to yield 1 g (92%) of 3-(chloromethyl)-2-(2-chlorophenyl)pyridine as a white solid.

Workup

  1. customInto a 25-mL round-bottom flask, was placed
  2. temperatureat reflux
  3. concentrationThe resulting mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-887340923f7749e4b7f9ffc560f78c93
Source dataset
uspto-grants-2016_08
Patent number
US09422279B2

Reaction notes

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