HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-dimethyl-4-nitrobenzenesulfonamide → Benzenesulfonamide, 4-amino-N,N-dimethyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-dimethyl-4-nitrobenzenesulfonamide | HCID 2747580 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Benzenesulfonamide, 4-amino-N,N-dimethyl- | HCID 74369 | 95% |
Reaction Steps
Under H2, N,N-dimethyl-4-nitrobenzenesulfonamide (879 mg, 3.8 mmol, 1.0 equiv.) was catalytically hydrogenated in the presence of Pd/C (40 mg) in MeOH (25 mL). When no more H2 was consumed, the reaction mixture was filtered. The filtrate was concentrated and crystallized to afford compound 4-amino-N,N-dimethyl benzenesulfonamide (722 mg, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09422271B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-516b0c9b1bff4851872f7983c660b89c |
| Source note | uspto-grants-2016_08 |