3-cyclopropyl-1H-pyrazol-5-amine → HCID 58169520, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-(4-chloro-5-nitropyrimidin-2-yl)phenyl)acetonitrile (55 mg, 0.2 mmol, 1 equiv.) and 5-cyclopropyl-1H-pyrazol-3-amine (37 mg, 0.3 mmol, 1.5 equiv.) in ethanol (2 ml) was stirred at 85° C. for 15 h. Ethanol was remove under reduce pressure. The residue was purified by silica gel chromatography (CH2Cl2/methanol 500:1 to 100:1) to afford 2-(4-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-nitropyrimidin-2-yl)phenyl)acetonitrile (45 mg, 62%) as solid. The compound was determination by LC-MS (LC-MS (m/z)=362.1 [M+H]+).

Provenance & Evidence