反应详情

A mixture of N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-phenylpyrimidine-4,5-diamine (350 mg, 1.19 mmol, 1.0 eq) and Ac2O (12 mL) was stirred at rt for 3 h and concentrated. The residue was dissolved in MeOH (3 mL). Sat. aqueous NaOH was added dropwise until pH=12 and stirred for 10 minutes. The final mixture was concentrated and purified by silica gel chromatography (hexane/EtOAc=10:1 as eluent)) to obtain target product N-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2-phenylpyrimidin-5-yl)acetamide.

1. concentrationconcentrated
2. dissolutionThe residue was dissolved in MeOH (3 mL)
3. additionSat. aqueous NaOH was added dropwise until pH=12
4. stirringstirred for 10 minutes
5. concentrationThe final mixture was concentrated
6. custompurified by silica gel chromatography (hexane/EtOAc=10:1 as eluent))