Ethyl 2,4-dichloropyrimidine-5-carboxylate → HCID 58169488, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 2,4-dichloropyrimidine-5-carboxylate (3.6 g, 16.3 mmol, 1.0 equiv.) and 5-cyclopropyl-1H-pyrazol-3-amine (3.0 g, 24.45 mmol, 1.5 equiv.) in EtOH (6 mL) was stirred at 20° C. under a nitrogen atmosphere for 10 min. The reaction mixture was filtered and the solid was washed by EtOH (10 mL) and MeOH (3 mL) to afford ethyl 2-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidine-5-carboxylate (3.5 g, 70%) as a white solid. LC-MS (m/z)=308.1 [M+H]+.

Provenance & Evidence