Phosphorus oxychloride → HCID 58169121, compound

Participants

Reaction Steps

A solution of 5-nitro-2-(pyridin-2-yl)pyrimidin-4-ol (1.74 g, 0.008 mmol, 1 equiv.) in POCl3 (6.12 g, 0.04 mmol, 5 equiv.) was refluxed for 3 h. Then, the mixture was poured into ice (200 g), extracted with EA (200 mL×2). The combined organic phases were evaporated to afford 4-chloro-5-nitro-2-(pyridin-2-yl)pyrimidine (1.5 g, 80%). LCMS: 237 [M+H]+.

Provenance & Evidence