Ammonium Chloride → HCID 58169570, compound

Participants

Reaction Steps

A mixture of N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-nitro-2-(pyridin-2-yl)pyrimidin-4-amine (1.29 g, 0.004 mmol, 1 equiv.) and Fe (2.24 g, 0.04 mmol, 10 equiv.) in ethanol and aqueous NH4Cl (2.12 g, 0.04 mmol, equiv.) was bubbled with N2, and refluxed for 1 h. Then, the reaction mixture was filtered. The liquid was evaporated to afford N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(pyridin-2-yl)pyrimidine-4,5-diamine (1.0 g, 85%). LC-MS (m/z)=294 [M+H]+.

Provenance & Evidence