Sodium Carbonate → N-tert-butyl-5-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)thiophene-2-sulfonamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine (300 mg, 1.071 mmol, 1.0 eq), N-tert-butyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-sulfonamide (443.7 mg, 1.285 mmol, 1.2 eq), Pd(dppf)Cl2 (87.5 mg, 0.1071 mmol, 0.1 eq), Na2CO3 (454.1 mg, 4.284 mmol, 4 eq) in 1,4-dioxane (20 ml) and water (4 ml) was stirred at 100° C. under a nitrogen atmosphere for 15 h. The reaction mixture was allowed to cool to room temperature and concentrated to give a residue, which was purified by silica gel chromatography (CH2Cl2/methanol 500:1 to 50:1 as eluent) to afford N-tert-butyl-5-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)thiophene-2-sulfonamide (300 mg, 66.9%) as a solid. LC-MS (m/z)=419.1 [M+H]+.

Provenance & Evidence