5-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thiophene-2-sulfonamide → 5-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-5-methyl-pyrimidin-2-yl]thiophene-2-sulfonamide

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Reaction Steps

5-(4-(5-Cyclopropyl-1H-pyrazol-3-ylamino)-5-methylpyrimidin-2-yl)thiophene-2-sulfonamide (Compound 40) (43 mg, 24.8%) was prepared following same procedure as described in Compound 50 by starting with 2-bromo-5-methyl-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine. LC-MS (m/z)=377.0 [M+H]+; 1H NMR (400 MHz, DMSO-d6): 0.75-0.76 (m, 2H), 0.97-0.99 (m, 2H), 1.93-1.95 (m, 1H), 2.18 (s, 3H), 6.51 (s, 1H), 7.57 (d, J=3.6 Hz, 1H), 7.73 (d, J=3.2 Hz, 1H), 7.78 (s, 2H), 8.14 (s, 1H), 9.13 (s, 1H), 12.17 (s, 1H).

Provenance & Evidence