Trifluoroacetic acid → Trifluoroacetic acid

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Reaction Steps

A mixture of (Z)-tert-butyl amino(5-(5-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)thiophen-2-yl)methylenecarbamate (Compound 328) (60 mg, 0.13 mmol) and TFA (2 mL) in DCM (2 mL) was stirred at room temperature for 1 h. The solvent was distilled and recrystallized with ether (2 mL) to afford get 5-(5-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)thiophene-2-carboximidamide (Compound 205) as TFA salt (55 mg, 72%). LC-MS (m/z)=360 [M+H]+; 1H NMR (400 MHz, DMSO-d6): δ 0.77-0.81 (m, 2H), 0.97-1.01 (m, 2H), 1.97-2.01 (m, 1H), 6.43 (s, 1H), 7.90 (d, J=4.0 Hz, 1H), 8.01 (d, J=4.0 Hz, 1H), 8.50 (s, 1H), 9.34 (s, 2H), 9.44 (s, 2H), 9.56 (s, 1H).

Provenance & Evidence