3-cyclopropyl-1H-pyrazol-5-amine → HCID 58169492, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of the crude N-tert-butyl-5-(5-chloro-4-(methylsulfinyl)pyrimidin-2-yl)furan-2-sulfonamide and 5-cyclopropyl-1H-pyrazol-3-amine (255 mg, 2.08 mmol, 5.0 equiv.) in n-butanol (6 mL) was stirred at 90° C. for 2 h, then, partitioned between brine and ethylacetate. The organic layer was washed over brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography to afford N-tert-butyl-5-(5-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)furan-2-sulfonamide (45 mg, 28% over 2 steps). LC-MS (m/z)=437.0 [M+H]+.

Provenance & Evidence