HCID 50943608, compound → HCID 67266851, compound

HRID 1484919Notes

Reaction equation

HRID 1484919 reaction equation
[CH:1]1([C:4]2[NH:8][N:7]=[C:6]([NH:9][C:10]3[C:15]([Cl:16])=[CH:14][N:13]=[C:12]([C:17]4[S:21][C:20]([C@@H:22]([OH:24])[CH3:23])=[CH:19][CH:18]=4)[N:11]=3)[CH:5]=2)[CH2:3][CH2:2]1.C1(C2NN=C(NC3C(Cl)=CN=C(C4SC([C@H](O)C)=CC=4)N=3)C=2)CC1>>[CH:1]1([C:4]2[NH:8][N:7]=[C:6]([NH:9][C:10]3[C:15]([Cl:16])=[CH:14][N:13]=[C:12]([C:17]4[S:21][C:20]([CH:22]([OH:24])[CH3:23])=[CH:19][CH:18]=4)[N:11]=3)[CH:5]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 50943608HCID 50943608, compound2×HCID 58169325HCID 58169325, compound2×

Product 1

HCID 67266851HCID 67266851, compound

Procedure

Following the 5-fluoro analogs, (S)-1-(5-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-chloropyrimidin-2-yl)thiophen-2-yl)ethanol (Compound 132) (4 mg) and (R)-1-(5-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-chloropyrimidin-2-yl)thiophen-2-yl)ethanol (Compound 131) (3.7 mg) were prepared. Both had LC-MS: 362.1 [M+H]+.

Workup

  1. customwere prepared

Sources & evidence

ORD record
ord-eebd4210a0774939af9b1848253506b4
Source dataset
uspto-grants-2016_08
Patent number
US09422271B2

Reaction notes

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