HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1484932Generated: October 31, 2026
N-bromobutanimide → N-(3-(5-bromothiophen-2-ylthio)propyl)acetamide
https://huagongshe.com/reaction/1484932
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | N-(3-(thiophen-2-ylthio)propyl)acetamide | HCID 58169495 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(3-(5-bromothiophen-2-ylthio)propyl)acetamide | HCID 58169293 | 46.9% |
Reaction Steps
A mixture of N-(3-(thiophen-2-ylthio)propyl)acetamide (2.5 g, 11.6 mmol, 1.0 eq), NBS (2.1 g, 11.6 mmol, 1.0 eq) in DMF (5 mL) was stirred at 23° C. for 1 hour. The mixture was extracted with CH2Cl2. The combined organic layers were dried (Na2SO4), filtered and concentrated to give yellow oil N-(3-(5-bromothiophen-2-ylthio)propyl)acetamide (1.6 g, 46.8%);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09422271B2 |
|---|
| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-88c9a294fb1641bba8c26173ec370256 |
|---|
| Source note | uspto-grants-2016_08 |
|---|
