Aluminium lithium hydride → HCID 86651551, compound

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Reaction Steps

To the solution of ethyl 2-bromo-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidine-5-carboxylate (3.0 g, 8.5 mmol, 1 eq) in THF (300 ml) at −78° C., LiAlH4 (3.0 g) was added slowly. After stirring at RT for 1 h, Na2SO4.H2O was added and stirred at 23° C. for 0.5 h. The mixture was filtered and extracted with EtOAc (3×50 ml). The combined organic phases were washed (brine), dried (Na2SO4), filtered and concentrated to give a residue. The residue was purified by silica gel column chromatography (PE/EtOAc=1:1 as eluant) to give (2-bromo-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidin-5-yl)methanol (450 mg, 17.03%) as white solid. LC-MS (m/z)=311.15 [M+H]+

Provenance & Evidence